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For peptides that do not dissolve cleanly in bacteriostatic water alone — typically those with hydrophobic sequences or basic amino acid-rich compositions that require protonation for solubilisation — the recommended approach is to first perform initial reconstitution in a small volume of 0.1% acetic acid water (also available from Peptides Lab UK) to produce a clear stock solution, before diluting further with bacteriostatic water or the relevant physiological buffer

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In PA patients the parietal cells that produce intrinsic factor is destroyed due to an autoimmune reaction that also leads to an atrophic gastritis