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Cheung R, Tucker S, Ye J, Dong L, Liu H, Huang E, Mohan R , Kuban D

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used the cryo-EM structure of the SSX1 carboxy terminus bound to an H2AK119ub-decorated nucleosome to show that SSX1 binding depends on a cryptic basic groove formed by H3 and the monoubiquitin motif on H2A [31], and in doing so induces DNA unwrapping that likely facilitates transcription factor binding