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40,41 Complementary mouse studies extended these findings, demonstrating that reactive astrocytes, characterized by hypertrophy and elevated MAOB expression, produced excessive tonic GABA inhibition, impairing fear extinction retrieval (Study 4)

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Additional support for GRK phosphorylation of these sites comes from methods that measure pan-phosphorylation combined with disruption of β -arrestin2 translocation to the surface membrane and/or disruption of endocytosis after exposure to highly efficacious agonists such as DAMGO or etorphine

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