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Indeed, vitamin B12 is the cofactor of methionine synthase, which is implicated in methylation reaction and in the synthesis of purine bases 29,30 , and these functions are crucial in tumor-initiating cells and cell proliferation 30,31

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METHODS: Animals were randomly allocated to sequentially receive atropine (0.12 mg/kg by rapid injection), pralidoxime (25 mg/kg by injection during 2 minutes), and hydroxocobalamin (75 mg/kg during 10 minutes) by the intravenous or intraosseous route, or atropine and pralidoxime by the intramuscular route