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Co-crystal structures of GPX4 U46C in complex with reversible peptide binders have been reported, but their relevance remains unknown given that these compounds are unable to inhibit cellular GPX4 (Sakamoto et al

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Thereafter, the removed native tissue was either replaced into the mid-stromal pocket in five minipigs (control autograft group), or a 280-µm-thick, 7-mm-diameter BPCDX was inserted in the remaining five minipigs