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Interaction with Other Signaling Pathways In addition to its direct effects on gene transcription and rapid signaling pathways, estrogen interacts with a variety of other signaling systems that influence brain function
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Adult zebrafish ( Danio rerio ) brain after exposure to R-(−)-/S-(+)-/rac-IBU at 5 μg/L for 28 days showed stereoselective alterations in the 45 identified biomarkers from the untargeted metabolomics analysis, with 22 amino acids quantitated, and 3 antioxidant enzymes [64], indicating that ibuprofen enantiomers have different effects
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