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119,120,121,122 The canonical Wnt signalling pathway affects the proliferation and differentiation of mesenchymal stem cells (MSCs) and osteoblast progenitor cells, as well as the bone resorption of osteoclasts, contributing to bone formation and playing an indispensable role in the maintenance of bone homeostasis

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Because of its potential to enhance metabolic efficiency and endurance, MOTS-c is on the WADA Prohibited List in category S4