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The current paper revisits principles previously identified to be common in Blue Zones and to be contributing to longevity ( move naturally, eat wisely, improve resilience to stress, get adequate sleep, keep strong family ties, stimulate strong community support, respect for the planet and having a purpose in life’ ), compares these to the 6 pillars of Lifestyle Medicine ( healthy eating , exercising , avoidance of smoking and other risky substances , stress management , restorative sleep, and forming and maintaining relationships) and reviews new studies investigating the association between behavioral factors and longevity