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Also, metabolites belonged to multiple lipid biosynthesis pathways (e.g., phospholipid biosynthesis, de novo triacylglycerol biosynthesis, inositol phosphate metabolism, sphingolipid metabolism, glycerolipid metabolism, glycerol phosphate shuttle, cardiolipin biosynthesis, phosphatidylcholine biosynthesis, phosphatidylethanolamine biosynthesis) which reflects the anabolic capacity of lipid macromolecules, were diminished as well (Fig
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