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Upon stimulation of the C-X-C chemokine receptor-7 (CXCR7) by SDF1, EPCs secrete pro-angiogenic cytokines and promote angiogenesis (252, 253)

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Research demonstrates that collagen peptides working through TGF-β/Smad3 pathway activation can reduce MMP-3, MMP-13, MMP-2, and MMP-9 activity while increasing procollagen synthesis, attenuating the collagen degradation characteristic of photoaged skin