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Translating 10 mg/kg/day in mice to a human equivalent dose using body surface area scaling (the standard FDA preclinical conversion, dividing by a factor of roughly 12 for mouse to human) yields an approximate human equivalent in the low single-digit mg/kg range, but this conversion is a rough regulatory starting point for safety studies, not a dosing prescription

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Pushing the plunger too quickly increases pressure inside the muscle and creates a sharper ache