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MiR-339-59/VEGFA has been shown to be an essential pathway for protecting neurons from apoptosis in rat brains following brain bleeds and strokes
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ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14
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