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In addition to oligonucleotide therapeutics, some small-molecule NNMT inhibitors have been reported recently [56–59] and several have shown effectiveness in the prevention or treatment of obesity and T2D in vitro [60, 61] or in preclinical animal models [10, 58, 62], validating NNMT as a pharmacological drug target

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Best for everyday: Biotics Research B12-2000™ Vitamin B12 Sublingual Lozenges Highly bioavailable B12 (as hydroxocobalamin) plus active Vitamin B6 (as pyridoxal-5-phosphate) and folate (as calcium folinate)