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The effect of citicoline was also evaluated in a multicenter, open-label, controlled trial (IDEALE trial) in Italian elderly adults (ages, 65-94 years) with evidence of vascular lesions on neuroradiology and mild-to-moderate cognitive deficits, as assessed by Mini-Mental State Examination (MMSE
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Figure 3 By influencing metabolic pathways, KD can also indirectly modulate NAD + /NADH levels, which play an important role in maintaining redox homeostasis (127)
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