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INDICATIONS AND DOSE Opioid-induced constipation [previous treatment with a laxative] ▶ BY MOUTH Adult: 25 mg once daily, to be taken in the morning DOSE ADJUSTMENTS DUE TO INTERACTIONS ▶ Manufacturer advises reduce initial dose to 12.5 mg daily with concurrent use of moderate inhibitors of CYP3A4, increasing to 25 mg daily if well tolerated