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Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation

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Studies using models of mutant ataxin-3 showed significant changes in the phosphorylation patterns of the PI3K/AKT/GSK3/mTOR pathway, leading to altered ataxin-3 signaling, dysregulated activation of the pro-survival ERK pathway, and diminished pro-apoptotic responses, all of which may contribute to disease progression 96

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