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10.1007/s00204-024-03768-5 [DOI] [PMC free article] [PubMed] [Google Scholar] Warburg O, Wind F, Negelein E (1927) The metabolism of tumors in the body

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The answer is that liver damage from acetaminophen occurs when the glutathione pathway is overwhelmed by too much acetaminophen's metabolite, NAPQI

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