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The combined indicator of vitamin B 12 status, cB 12 , is defined as: cB 12 = log10((holo-TC.B 12 )/(MMA.tHcy))−(age factor) (Fedosov et al., 2015), and thus, it differs from the “if → then” structure of classic diagnostic algorithms

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Pravat K Mandal, Anshika Goel, Ashley I Bush, Khushboo Punjabi, Shallu Joon, Ritwick Mishra, Manjari Tripathi, Arun Garg, Natasha K Kumar, Pooja Sharma, Deepika Shukla, Scott Jonathan Ayton, Amir Fazlollahi, Joseph C Maroon, Divya Dwivedi, Avantika Samkaria, Kanika Sandal, Kanu Megha, Sandhya Shandilya, Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimer’s disease compared with healthy elderly participants, Brain Communications, Volume 4, Issue 5, 2022, fcac215, Watanabe F, Hashizume E, Chan GP, Kamimura A