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This point stands in stark contrast to the many hundreds of publications probing mechanisms of action in cell culture and animal models

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(Guidance on consideration of important factors in the classification of carcinogenicity and a more detailed description of the terms "limited" and "sufficient" have been developed by the International Agency for Research on Cancer (IARC) and are provided in non-mandatory appendix F of this section.) A.6.2.5 Weight of evidence : Beyond the determination of the strength of evidence for carcinogenicity, a number of other factors should be considered that influence the overall likelihood that an agent may pose a carcinogenic hazard in humans