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The mechanism underlying facilitation involves circuits connecting with the PVT (14), further suggesting an important role for this region in integrating stress ‘chronicity’

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Keywords: Glucagon, Glucagon-like peptide-1 receptor agonist, Glucose-dependent insulinotropic peptide receptor, Incretin, Obesity, Type 2 diabetes mellitus Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]