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Although in this study and in our previous study [23] on HepG2 cells, we have used ASA to elucidate COX-independent mechanisms of drug action, there are reports that suggest that salicylate, an active metabolite of aspirin, has more or less similar mechanisms of action on mitochondrial-induced apoptosis [30], [31]
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Studies have demonstrated that glutamine positively regulates the mTORC1 pathway when promoting leucine uptake (161) and as well-boosting mTORC1 assembly as well as its localization into the lysosome
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