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Severely compromised occludin expression has been observed in disease models of intestinal inflammatory diseases, which suggests it has a critical role in the maintenance of barrier integrity 38,39,40
Farbstofffrei
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Therefore, in vitamin B12 deficiency, methylmalonic acid accumulates in the blood and is excreted by the kidneys in increased amounts in the urine, resulting in methylmalonic aciduria (Norman & Morrison, 1993)
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