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Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif)

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(2023) further found that in SK-N-BE neuroblastoma cells, 24-OHC could inhibit the formation of NFT and reverse neuronal death through its action on the SIRT1/PGC1α/ Nrf2 signaling pathway, promote the activation of the UPS system, and inhibit the excessive accumulation of Tau protein through the ubiquitination and degradation function of UPS, which in turn prevents the formation of NFTs, reverses neuronal death, and exerts neuroprotective effects