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In addition to DNA methylation, some histone modifications (e.g., methylation like H3K4me3, acetylation like H3K27ac) have been reported to play an important role in the epigenetic regulation of GPX4 [42,43]

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In 2009, the EMEA (European Medicine Agency) withdrew market authorisation for rimonabant in all countries of the European Union due to safety concerns [21]