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Gastrointestinal disorders were the most common adverse events with semaglutide, typically transient, of mild-to-moderate severity, occurring during dose escalation, and infrequently leading to treatment discontinuation

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However, expression of other pro-inflammatory macrophage markers F4/80 and Cd11b , and T cell markers Cd4 and Cd8a , and B cell marker Cd19 was unchanged in Cpt1b m−/− muscle compared to control Cpt1b fl/fl muscle (Fig