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The most common side effects from testosterone treatment are: [6] Acne and/or oily skin Fluid retention Stimulation of prostate tissue, which can result in decreased urine flow and frequency Development of breast tissue Worsening of sleep apnea Shrinking of the testes Decreased sperm count/infertility Increase in red blood cell count Changes in cholesterol levels Like any serious medical treatment, the decision to receive testosterone treatment shouldn't be made lightly