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The major ROS-affected pathways in response to arsenic include Nrf2-antioxidant response element (ARE) signaling pathway, microRNAs (miRNAs), mitophagy pathway, tyrosine phosphorylation system, mitogen-activated protein kinases (MAPKs), nuclear factor κB (NF-κB), and activator protein-1 (AP-1) [47,48,49,50] (Table 1)

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