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The following parameters are recommended at baseline and at 8 weeks: Fasting glucose and insulin (to calculate HOMA-IR) HbA1c Fasting lipid panel (total cholesterol, LDL, HDL, triglycerides) Comprehensive metabolic panel (liver and renal function) IGF-1 (to verify AOD-9604 is not elevating IGF-1 above age-adjusted reference range) Blood pressure and resting heart rate Body composition assessment (DEXA or bioimpedance) at baseline and 12 weeks The CDC's chronic disease prevention framework recommends structured metabolic monitoring for any intervention targeting adiposity or insulin metabolism in adults with obesity or pre-diabetes [13]
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