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The study by Shao and co-authors, using Grx1 −/− mice model, showed the importance of this redoxin in regulating hepatic lipid homeostasis and preventing fatty liver disease via regulation of glutathionylation of the histone deacetylase sirtuin1

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The potential protective action of β-catenin was due to the activation of the PI3K/Akt pathway and thus the reduction of TLR4-driven inflammatory response in hepatocytes 107