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Preclinical findings in mice frequently do not replicate in humans, particularly in metabolic research, where multiple prior "promising" targets have failed at the human trial stage

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The STEP 1 trial, published in the New England Journal of Medicine , demonstrated that participants receiving semaglutide 2.4 mg weekly lost an average of 14.9 percent of their body weight over 68 weeks, compared to 2.4 percent with placebo (Wilding et al., 2021)