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This peptide’s development is rooted in the groundbreaking discovery that hyperphosphorylated RB functions as a potent suppressor of NF-κB activity and PD-L1 transcription, unveiling a previously unknown tumor suppressor role of RB (Burkhart and Sage, 2008)

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As expected, in ligature induced experimental periodontitis, a considerable increase in vascular permeability in the gingival tissue was detected