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USA 93:7269-7273 (1996)
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Notoginseng leaf triterpenes (NLTs), a compound derived from Panax notoginseng, protected against cerebral ischemia and oxygen-glucose deprivation/reoxygenation-induced neuronal injury by activating the nicotinamide phosphoribosyltransferase–sirtuin (SIRT)1/2/3–Forkhead box O3 (Foxo3a)–MnSOD signaling pathway, demonstrating MnSOD’s role as a key effector in NAD + -dependent antioxidant defenses [209,210]
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