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Most people think metabolism is just about calories. It's not. Your cells, energy production, inflammation pathways, NAD+ availability, and metabolic signaling all play a role in how efficiently the body functions. That's
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In fact, CD38 knockout mice exhibit significant increases in both extra- and intracellular NAD + levels ( Because of its ability to use NAD + as a substrate, CD38 has been hypothesized to act as a metabolic sensor, limiting the duration of NAD + half-life and signaling in the extracellular compartment
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