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(Karankar et al., 2025) Nucleic acid vaccination can enhance the production of pro-inflammatory cytokines (such as IFN-α, IL-6, and TNF-α) and stimulate pattern recognition receptors (e.g., TLR3, TLR7/8, STING), which leads to the maturation and activation of dendritic cells (Pardi et al., 2018)

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What this mechanism does NOT prove: Demonstrating lipolysis in adipocytes in cell culture, or weight reduction in diet-induced obese mice, does not predict the magnitude or even direction of effect in humans with normal or high caloric intake