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This study also demonstrated upregulation of hypoxia-inducible enzyme heme oxygenase-1 (HO-1) and the anaerobic glycolytic enzyme lactate dehydrogenase, and increased generation of superoxide radicals in the retina and ONH, as well as the active subunit of the superoxide-generating enzyme NADPH oxidase, suggesting the involvement of oxidative stress [36]

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Gout and the risk of dementia: a nationwide population-based cohort study