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At a glance Drug / isotretinoin (Accutane), an oral retinoid for severe nodular acne Supplement / N-acetylcysteine (NAC), a glutathione precursor and mucolytic Known pharmacokinetic interaction / none identified in current literature Pharmacodynamic overlap / both modulate oxidative stress and redox balance Liver signal / a 2022 RCT (N=60) found NAC 600 mg twice daily reduced isotretinoin-related ALT elevation iPLEDGE requirement / any supplement must be disclosed to your prescriber

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Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance