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The ingestion of dietary fats and the oxidative metabolism of ethanol alter ER inducing ER stress, which emerges as a critical trigger to cause increased de novo lipogenesis, including free fatty acids (FFAs) and cholesterol via activation of transcription factors SREBP1c and SREBP2, respectively, with the ultimate impact in the onset of hepatic steatosis
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The use of green tea extract and curcumin is worth mentioning
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