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Similarly, Fuhr and colleagues71 noted an 80% increase in serum clozapine levels resulting from treatment with the CYP1A2 inhibitor fluoroquinolone.72 In a randomized double-blind crossover study, Raaska and Neuvonen73 found that individuals with schizophrenia who were clinically stable with clozapine treatment had a significant increase in plasma clozapine and N -desmethylclozapine levels when treated additionally with ciprofloxacin as compared with placebo