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Incubation of 50 μm rosmarinic acid with B16 melanoma cells for 48 h resulted in a significant increase in melanin content and tyrosinase protein expression, the mechanism being that rosmarinic acid induces melanin synthesis by activating the PKA/CREB signaling pathway via phosphorylation (Shomirzoeva et al., 2019)

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In accordance with section 1895(b)(3)(D)(iii) of the Act, the temporary adjustment is to be applied on a prospective basis and shall apply only with respect to the year for which such temporary increase or decrease is made