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As a structural analog within the copper peptide class, it has been examined alongside GHK-Cu in preclinical models investigating copper-dependent enzymatic activity, extracellular matrix remodeling, and cellular signaling pathways relevant to skin and connective tissue biology

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This creates a situation where a Medicare patient with both type 2 diabetes and obesity might receive tirzepatide covered as Mounjaro for diabetes, with weight loss as a secondary benefit