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104,105 Immunoblot results revealed that overexpression of the E3 ubiquitin ligase carboxyl-terminus-of-HSP70-interacting protein (CHIP) in COS7 cells induces the ubiquitination of phosphorylated tau in collaboration with E2 ubiquitin conjugating enzyme UbcH5B, 106 suggesting the importance of UPS in maintaining tau equilibrium

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