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Following 9 weeks of 4mg daily dietary astaxanthin supplementation, the MED levels increased more than fourfold, indicating that astaxanthin protects the skin from UV radiation damage.[4] In another study, human dermal fibroblasts were exposed to UVA radiation followed by the addition of astaxanthin which was shown to reduce MMP-1 and enzyme that breaks down the interstitial collagen.[5] Fine Line Reduction Smoother, Flawless Skin Both oral and topical use of astaxanthin have shown to help reduce the appearance of fine lines and wrinkles

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Therefore, selenium deficiency might increase the potential for lymphedema as an additional risk factor