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Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of Stat1 phosphorylation

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However, HCl downregulates the expression of E-cadherin, a transmembrane glycoprotein essential for cellular junction integrity, resulting in increased intercellular permeability and, thus, damage to the oesophageal mucosa (Reference Jovov, Que and Tobey30)