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The intestinal barrier can become damaged from a variety of factors, including: A poor diet, high in processed carbohydrates and hydrogenated oils Food sensitivities Certain gut-irritating foods, such as grains, legumes, dairy and alcohol Low stomach acid Chronic stress Hormonal imbalances Medications, such as NSAIDS, antibiotics, steroids, contraceptives and chemotherapy drugs Chronic endurance exercise and overtraining Environmental toxins Infections and parasites Imbalance of the gut flora