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Frequency Limitations Medicare and commercial payers often limit testing to 2–4 times annually , depending on patient condition

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Various PKC isoforms (PKCα, β II, γ, ε) activated by phorbol 12-myristate 13-acetate (PMA) trigger MOR phosphorylation at S363 and T370 but those kinases are not recruited upon DAMGO stimulation (Doll et al., 2011