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Therefore, the depression of energy expenditure caused by NNMT overexpression cannot be explained solely by the competition between NNMT and NAD + salvaging

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In pro-repair, it activates the MAPK/ERK signaling pathway to stimulate dermal fibroblast proliferation and promote collagen synthesis, while exerting antioxidant effects through free radical scavenging and pro-oxidative metal ion chelation, supporting tissue regeneration and skin rejuvenation at the molecular level