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Risk factors include: Overuse of the knee joint Uncontrolled diabetes Weakness in the quadriceps muscles Use of certain medications such as corticosteroids Previous knee surgery or injury Chronic patellar tendonitis or tendinosis Medical conditions such as lupus, chronic kidney disease, and rheumatoid arthritis Patellar tendon rupture is usually the result of long-standing tendon degeneration

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Neuron 110 , 2984–2999.e8 (2022)