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The median baseline top-quadrant SALT score was 40.0% (interquartile range: 23.8% to 50.0%), which reduced to 7.5% (interquartile range: 0% to 17.5%) at 5 months (Wilcoxon signed-rank test, P 10%

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RBD is an attractive vaccine target because it elicits high-quality, functionally relevant antibodies, while avoiding the potential risk of ADE, which is generally thought to be mediated by weak nAbs or non-nAbs 24,30,104