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DSIP (Delta Sleep-Inducing Peptide) has one of the longer and more unusual research histories of any compound in this article series — discovered in the 1970s during an active scientific hunt for the body's endogenous "sleep factor," and still, decades later, sitting in a genuinely unresolved position: a molecule with real, if small, human trial data behind it, but no settled understanding of its actual physiological role, and no modern, adequately powered trial to clarify the picture

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We asked how mutation/deletion of Cu-binding sites in PrP-ΔOR, PrP-Ala-1, and PrP-Ala-2 affected PrP endocytosis in ATP7B-KO cells