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Some channels belong to the group of the ligand-gated channels, which requires the binding of a ligand to the receptor region to modify their conformation and be opened or closed (145, 146)

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Response of IGF1 Signaling Pathway to Radiation Heavy-ion 56 Fe radiation led to increased serum IGF1 levels 2 months after exposure and decreased IGFBP-3 levels in serum along with increased IGF1R in tissues (Suman et al., 2016)